Strangles in horses can be caused by vaccination with Pinnacle I. N

Ray Cursons; Olivia Patty; Karen F Steward; Andrew S Waller

doi:10.1016/j.vaccine.2015.05.009

Strangles in horses can be caused by vaccination with Pinnacle I. N

Vaccine. 2015 Jul 9;33(30):3440-3. doi: 10.1016/j.vaccine.2015.05.009. Epub 2015 May 27.

Authors

Ray Cursons¹, Olivia Patty¹, Karen F Steward², Andrew S Waller³

Affiliations

¹ School of Science, University of Waikato, Hamilton, New Zealand.
² Animal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, United Kingdom.
³ Animal Health Trust, Lanwades Park, Kentford, Newmarket CB8 7UU, United Kingdom. Electronic address: andrew.waller@aht.org.uk.

PMID: 26025806
DOI: 10.1016/j.vaccine.2015.05.009

Abstract

The differentiation of live attenuated vaccine strains from their progenitor and wild-type counterparts is important for ongoing surveillance of product safety and improved guidelines on their use. We utilised a genome sequencing approach to confirm that two cases of strangles in previously healthy horses that had received the Pinnacle I. N. vaccine (Zoetis) were caused by the vaccine strain. Our data shed new light on the safety of this vaccine and suggest that factors beyond the maturity of the animal's immune system influence the development of adverse reactions.

Keywords: Adverse effects; Pinnacle; Reversion; Strangles; Vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bacterial Vaccines / administration & dosage
Bacterial Vaccines / adverse effects*
DNA, Bacterial / chemistry
DNA, Bacterial / genetics
Drug Contamination
Genome, Bacterial
Horse Diseases / chemically induced*
Horses
Respiratory Tract Infections / chemically induced
Respiratory Tract Infections / veterinary*
Sequence Analysis, DNA
Streptococcal Infections / chemically induced
Streptococcal Infections / veterinary*
Streptococcus equi
Vaccination / adverse effects*

Substances

Bacterial Vaccines
DNA, Bacterial