Advances in measuring single-cell pharmacology in vivo

Claudio Vinegoni; J Matthew Dubach; Greg M Thurber; Miles A Miller; Ralph Mazitschek; Ralph Weissleder

doi:10.1016/j.drudis.2015.05.011

Advances in measuring single-cell pharmacology in vivo

Drug Discov Today. 2015 Sep;20(9):1087-92. doi: 10.1016/j.drudis.2015.05.011. Epub 2015 May 27.

Authors

Claudio Vinegoni¹, J Matthew Dubach², Greg M Thurber³, Miles A Miller², Ralph Mazitschek², Ralph Weissleder²

Affiliations

¹ Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address: cvinegoni@mgh.harvard.edu.
² Center for System Biology, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA.
³ Department of Chemical Engineering, Department of Biomedical Engineering, University of Michigan, 2300 Hayward Avenue, Ann Arbor, MI 48109, USA.

Abstract

Measuring key pharmacokinetic and pharmacodynamic parameters in vivo at the single cell level is likely to enhance drug discovery and development. In this review, we summarize recent advances in this field and highlight current and future capabilities.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Drug Design*
Drug Discovery / methods*
Humans
Models, Biological
Pharmacokinetics
Pharmacology
Single-Cell Analysis / methods*

Abstract

Publication types

MeSH terms

Grants and funding