Abstract
A novel C₂₅ sterol peroxide, phomasterol A (1), together with two known compounds (2-3), was isolated from the endophytic fungus Phoma sp. EA-122. The structure of phomasterol A (1) was elucidated by MS, 1D, and 2D NMR data analyses. Phomasterol A (1) was evaluated for its inhibitory activities against protein-tyrosine phosphatases MEG2 and PTP1Bc, showing moderate activities with identical IC₅₀ values of 25 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ascomycota / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peroxides / chemistry*
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Peroxides / isolation & purification
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Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
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Protein Tyrosine Phosphatases, Non-Receptor / antagonists & inhibitors
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Sterols / chemistry*
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Sterols / isolation & purification
Substances
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Peroxides
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Sterols
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phomasterol A
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PTPN1 protein, human
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PTPN9 protein, human
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Protein Tyrosine Phosphatase, Non-Receptor Type 1
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Protein Tyrosine Phosphatases, Non-Receptor