A novel C₂₅ sterol peroxide from the endophytic fungus Phoma sp. EA-122

Z Naturforsch C J Biosci. 2015;70(3-4):93-6. doi: 10.1515/znc-2014-4217.

Abstract

A novel C₂₅ sterol peroxide, phomasterol A (1), together with two known compounds (2-3), was isolated from the endophytic fungus Phoma sp. EA-122. The structure of phomasterol A (1) was elucidated by MS, 1D, and 2D NMR data analyses. Phomasterol A (1) was evaluated for its inhibitory activities against protein-tyrosine phosphatases MEG2 and PTP1Bc, showing moderate activities with identical IC₅₀ values of 25 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / chemistry*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peroxides / chemistry*
  • Peroxides / isolation & purification
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
  • Protein Tyrosine Phosphatases, Non-Receptor / antagonists & inhibitors
  • Sterols / chemistry*
  • Sterols / isolation & purification

Substances

  • Peroxides
  • Sterols
  • phomasterol A
  • PTPN1 protein, human
  • PTPN9 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases, Non-Receptor