Myrothecols g and h, two new analogues of the marine-derived quinone sesquiterpene penicilliumin A

Mar Drugs. 2015 May 27;13(6):3360-7. doi: 10.3390/md13063360.

Abstract

Two new quinone sesquiterpenes named myrothecols G and H (1 and 2), a pair of C-1' diastereomers of 13-hydroxyl penicilliumin A, were isolated from the mycelia solid cultures of Myrothecium sp. SC0265. Their structures, including the absolute configurations, were established on the basis of the spectroscopic data combining with the theoretical conformational analysis. The cytotoxic activities of 1 and 2 were tested against a panel of human tumor cell lines.

Keywords: 13-hydroxyl penicilliumin A; cytotoxicity; myrothecol G; myrothecol H; quinone sesquiterpenes; stereochemistry; theoretical conformational analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Benzoquinones / chemistry
  • Benzoquinones / isolation & purification
  • Benzoquinones / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Quinones / chemistry
  • Quinones / isolation & purification
  • Quinones / pharmacology*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Spectrum Analysis
  • Stereoisomerism

Substances

  • Antineoplastic Agents
  • Benzoquinones
  • Quinones
  • Sesquiterpenes
  • myrothecol G
  • myrothecol H
  • penicilliumin A