GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies

Xinan Wang; Hideki Muramatsu; Yusuke Okuno; Hirotoshi Sakaguchi; Kenichi Yoshida; Nozomu Kawashima; Yinyan Xu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Shoji Saito; Yozo Nakazawa; Taro Masunari; Tadashi Hirose; Shaimaa Elmahdi; Atsushi Narita; Sayoko Doisaki; Olfat Ismael; Hideki Makishima; Asahito Hama; Satoru Miyano; Yoshiyuki Takahashi; Seishi Ogawa; Seiji Kojima

doi:10.3324/haematol.2015.127092

GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies

Haematologica. 2015 Oct;100(10):e398-401. doi: 10.3324/haematol.2015.127092. Epub 2015 May 28.

Authors

Xinan Wang¹, Hideki Muramatsu¹, Yusuke Okuno¹, Hirotoshi Sakaguchi¹, Kenichi Yoshida², Nozomu Kawashima¹, Yinyan Xu¹, Yuichi Shiraishi³, Kenichi Chiba³, Hiroko Tanaka³, Shoji Saito⁴, Yozo Nakazawa⁴, Taro Masunari⁵, Tadashi Hirose⁶, Shaimaa Elmahdi¹, Atsushi Narita¹, Sayoko Doisaki¹, Olfat Ismael¹, Hideki Makishima⁷, Asahito Hama¹, Satoru Miyano⁸, Yoshiyuki Takahashi¹, Seishi Ogawa², Seiji Kojima⁹

Affiliations

¹ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
² Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.
³ Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan.
⁴ Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
⁵ Department of Hematology, Chugoku Central Hospital, Fukuyama, Japan.
⁶ Department of Hematology, Kawasaki Medical School, Okayama, Japan.
⁷ Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
⁸ Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan.
⁹ Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan kojimas@med.nagoya-u.ac.jp.

No abstract available

Keywords: GATA2; SETBP1; acute myeloid leukemia; aplastic anemia; children; familial myelodysplastic syndromes; juvenile myelomonocytic leukemia; monosomy 7.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Child
Family
GATA2 Transcription Factor / genetics*
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Mutation*
Myelodysplastic Syndromes / genetics*
Myeloproliferative Disorders / genetics*
Pedigree

Substances

GATA2 Transcription Factor