Migraine prevalence increases from infancy to adolescence thus suggesting the important role of adolescent somatic and emotional maturation in supporting the disease. New family and society relationship and scholastic experiences represent more or less stress moments, producing risk factors for adolescent migraine. There are few studies adequately assessing migraine treatment efficacy in adolescent attack and prevention. Adolescent migraine's treatment with pharmacological and nonpharmacological therapies needs an individualized approach considering adolescent development degree, risk factors and trigger circumstances, psychological correlates and even psychiatric or other comorbidities.