Abstract
We report the first OXA-181-producing strain in China. blaOXA-181 was found in sequence type 410 (ST410) Escherichia coli strain WCHEC14828 from a Chinese patient without recent travel history. Genome sequencing and conjugation experiments were performed. blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked with qnrS1, a quinolone resistance gene. blaOXA-181 was introduced onto the IncX3 plasmid from a ColE2-type plasmid, and IncX3 plasmids have the potential to mediate the dissemination of blaOXA-181.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Base Sequence
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China
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Conjugation, Genetic
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DNA, Bacterial / genetics
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Drug Resistance, Multiple, Bacterial / genetics
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Escherichia coli / drug effects*
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Escherichia coli / genetics*
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Escherichia coli / metabolism
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Escherichia coli Infections / drug therapy*
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Escherichia coli Proteins / genetics*
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids / genetics
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Sequence Analysis, DNA
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beta-Lactam Resistance / genetics*
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beta-Lactamases / biosynthesis
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beta-Lactamases / genetics*
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Escherichia coli Proteins
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beta-Lactams
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beta-Lactamases
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beta-lactamase OXA-181, E coli