Subcutaneous infection caused by Blastoschizomyces capitatus post allogeneic hematopoietic transplant and its successful treatment with voriconazole

Transpl Infect Dis. 2015 Aug;17(4):588-92. doi: 10.1111/tid.12404. Epub 2015 Jul 1.

Abstract

We describe a 33-year-old man with relapsed acute myelogenous leukemia who developed subcutaneous nodules >6 months after allogeneic hematopoietic stem cell transplant. These nodules were caused by Blastoschizomyces capitatus. The lesions progressed after treatment with a posaconazole suspension. The lesions resolved after switching to voriconazole, which was given for 21 weeks. B. capitatus is a rare infection affecting immunocompromised patients, which responds to azoles.

Keywords: Blastoschizomyces capitatus; hematopoietic transplant; rare fungal infection; voriconazole.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use*
  • Dermatomycoses / complications
  • Dermatomycoses / diagnosis
  • Dermatomycoses / drug therapy*
  • Dipodascus / isolation & purification*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / therapy*
  • Male
  • Opportunistic Infections / complications
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / drug therapy*
  • Voriconazole / therapeutic use*

Substances

  • Antifungal Agents
  • Voriconazole