Abstract
Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression. We consider what gaps exist in our understanding of its genetic, biochemical and biophysical functioning and how they might be addressed.
Keywords:
AAA+ ATPase; RNA polymerase; Sigma54; transcription.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Enhancer Elements, Genetic*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli Proteins / chemistry
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Escherichia coli Proteins / metabolism*
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Gene Expression Regulation, Bacterial
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Molecular Sequence Data
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RNA Polymerase Sigma 54 / chemistry
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RNA Polymerase Sigma 54 / metabolism*
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Sigma Factor / chemistry
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Sigma Factor / metabolism
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Transcription, Genetic
Substances
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Escherichia coli Proteins
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Sigma Factor
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rpoN protein, E coli
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RNA Polymerase Sigma 54