A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causing MYC up-regulation and concomitant loss of PVT1, miR-15/16 and DLEU7

Br J Haematol. 2016 Jan;172(2):296-9. doi: 10.1111/bjh.13482. Epub 2015 May 26.
No abstract available

Keywords: B-cell chronic lymphocytic leukaemia; MIR15A/MIR16-1; MYC; del(13q); translocation.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 13 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Fatal Outcome
  • Female
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • MicroRNAs / genetics
  • Middle Aged
  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-myc / biosynthesis
  • RNA, Long Noncoding / genetics
  • Translocation, Genetic*
  • Tumor Suppressor Proteins / genetics
  • Up-Regulation / genetics

Substances

  • DLEU7 protein, human
  • MIRN15 microRNA, human
  • MIRN16 microRNA, human
  • MicroRNAs
  • Neoplasm Proteins
  • PVT1 long-non-coding RNA, human
  • Proto-Oncogene Proteins c-myc
  • RNA, Long Noncoding
  • Tumor Suppressor Proteins