Regulation of TRPML1 function

Helen Waller-Evans; Emyr Lloyd-Evans

doi:10.1042/BST20140311

Regulation of TRPML1 function

Biochem Soc Trans. 2015 Jun;43(3):442-6. doi: 10.1042/BST20140311.

Authors

Helen Waller-Evans¹, Emyr Lloyd-Evans¹

Affiliation

¹ *School of Biosciences, Sir Martin Evans building, Cardiff University, Museum Avenue, Cardiff, CF15 8AZ, U.K.

PMID: 26009188
DOI: 10.1042/BST20140311

Abstract

TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / genetics*
Alzheimer Disease / pathology
Endosomes / genetics
Gene Expression Regulation
HIV Infections / genetics*
HIV Infections / pathology
Humans
Lysosomes / genetics
Mucolipidoses / genetics*
Mucolipidoses / pathology
Mutation
Transient Receptor Potential Channels / biosynthesis*
Transient Receptor Potential Channels / genetics

Substances

MCOLN1 protein, human
Transient Receptor Potential Channels