Potential antibacterial activity of coumarin and coumarin-3-acetic acid derivatives

Pak J Pharm Sci. 2015 May;28(3):819-23.

Abstract

Coumarin and coumarin-3-acetic acid derivatives were synthesized by reacting phenols with malic acid, ethyl acetoacetate and ethyl acetylsuccinate in appropriate reaction conditions. All synthesized compounds were subjected to test for their antimicrobial activities against variety of gram positive (Bacillus subtilis, Staphylococcus aureus) and gram negative bacterial stains (Shigella sonnei, Escherichia coli) by agar dilution method. Several of them exhibited appreciable good antibacterial activity against the different strains of gram positive and gram negative bacteria. These findings suggest a great potential of these compounds for screening and use as antibacterial agents for further studies with a battery of bacteria.

MeSH terms

  • Acetates / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects*
  • Coumarins / pharmacology*
  • Escherichia coli / drug effects*
  • Microbial Sensitivity Tests
  • Shigella sonnei / drug effects*
  • Staphylococcus aureus / drug effects*

Substances

  • Acetates
  • Anti-Bacterial Agents
  • Coumarins
  • coumarin