Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats

María A Manso; Marta Miguel; Jeanne Even; Rosario Hernández; Amaya Aleixandre; Rosina López-Fandiño

doi:10.1016/j.foodchem.2007.12.049

Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats

Food Chem. 2008 Jul 15;109(2):361-7. doi: 10.1016/j.foodchem.2007.12.049. Epub 2007 Dec 25.

Authors

María A Manso¹, Marta Miguel², Jeanne Even¹, Rosario Hernández³, Amaya Aleixandre⁴, Rosina López-Fandiño⁵

Affiliations

¹ Instituto de Fermentaciones Industriales (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
² Instituto de Fermentaciones Industriales (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain; Instituto de Farmacología y Toxicología (CSIC), Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain.
³ CDEAS, Hospital Central de la Defensa, Plaza del Ejército s/n, 28007 Madrid, Spain.
⁴ Instituto de Farmacología y Toxicología (CSIC), Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain.
⁵ Instituto de Fermentaciones Industriales (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address: rosina@ifi.csic.es.

PMID: 26003359
DOI: 10.1016/j.foodchem.2007.12.049

Abstract

This paper examines the effects of the long-term consumption of egg white hydrolysed with pepsin (hEW) on the antioxidant status and lipid profile of spontaneously hypertensive rats (SHR). The antioxidant capacity was measured by the oxygen radical absorbance capacity (ORAC) and the oxidative status by the malon-dialdehyde (MDA) assay. The lipid profile was analysed spectrophotometrically. The radical-scavenging capacity of the plasma was increased and the MDA concentration in the aorta was decreased in the SHR treated with 0.5g/kg/day of hEW. Our findings indicate that hEW played an important role in antioxidative defence of SHR and exerted a beneficial effect on the lipid profile, lowering triglycerides and total cholesterol without changing HDL levels. Therefore, hEW may be useful to prevent or reverse abnormalities associated with the metabolic syndrome and its complications, such as hypertension, oxidative stress and hyperlipidemia.

Keywords: Antioxidant status; Bioactive peptides; Egg white; Lipid profile; Spontaneously hypertensive rats.