Mitochondrial cardiomyopathy and related arrhythmias

Abstract

Mitochondrial dysfunction has been shown to be involved in the pathophysiology of arrhythmia, not only in inherited cardiomyopathy due to specific mutations in the mitochondrial DNA but also in acquired cardiomyopathy such as ischemic or diabetic cardiomyopathy. This article briefly discusses the basics of mitochondrial physiology and details the mechanisms generating arrhythmias due to mitochondrial dysfunction. The clinical spectrum of inherited and acquired cardiomyopathies associated with mitochondrial dysfunction is discussed followed by general aspects of the management of mitochondrial cardiomyopathy and related arrhythmia.

Keywords: Arrhythmia management; Arrhythmia mechanisms; Diabetic cardiomyopathy; Mitochondrial DNA mutation; Mitochondrial cardiomyopathy; Mitochondrial syndrome.