1 Department of Anaesthesia, University of Cape Town, Anzio Road, Observatory, Western Cape 7925, South Africa mike.james@uct.ac.za.
2 Department of Anaesthesia, University of Cape Town, Anzio Road, Observatory, Western Cape 7925, South Africa.
3 Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Mailpoint 810, Sir Henry Wellcome Laboratories, Faculty of Medicine, University of Southampton, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Mailpoint 27, D Level, Centre Block, Tremona Road, Southampton SO16 6YD, UK NIHR Southampton Respiratory Biomedical Research Unit, Southampton SO16 6YD, UK.