ASXL1 mutated chronic myelomonocytic leukemia in a patient with familial thrombocytopenia secondary to germline mutation in ANKRD26

Blood Cancer J. 2015 May 22;5(5):e315. doi: 10.1038/bcj.2015.41.

Authors

J Perez Botero¹, J L Oliveira², D Chen², K K Reichard², D S Viswanatha², P L Nguyen², R K Pruthi¹, J Majerus², P Gada³, N Gangat¹, A Tefferi¹, M M Patnaik¹

Affiliations

¹ Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
² Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
³ Minnesota Hematology and Oncology, Minneapolis, MN, USA.

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Breakage
Chromosome Disorders / complications
Chromosome Disorders / genetics*
Germ-Line Mutation*
Humans
Intercellular Signaling Peptides and Proteins
Leukemia, Myelomonocytic, Chronic / complications
Leukemia, Myelomonocytic, Chronic / genetics*
Male
Middle Aged
Nuclear Proteins / genetics*
Repressor Proteins / genetics*
Thrombocytopenia / complications
Thrombocytopenia / congenital*
Thrombocytopenia / genetics

Substances

ANKRD26 protein, human
ASXL1 protein, human
Intercellular Signaling Peptides and Proteins
Nuclear Proteins
Repressor Proteins

Supplementary concepts

Thrombocytopenia chromosome breakage