Two new illudin type sesquiterpenoids from cultures of Phellinus tuberculosus and Laetiporus sulphureus

J Asian Nat Prod Res. 2015;17(11):1054-8. doi: 10.1080/10286020.2015.1040774. Epub 2015 May 22.

Abstract

Chemical investigation on the cultures of Phellinus tuberculosus and Laetiporus sulphureus lead to the isolation of two new illudin-type sesquiterpenoids (phellinuin J and sulphureuine A). Their structures were elucidated by 1D, 2D NMR and MS spectroscopic data. These compounds were purposely evaluated for their cytotoxicity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.

Keywords: Hymenochaetaceae; Laetiporus sulphureus; Phellinus tuberculosus; phellinuin J; sesquiterpenoids; sulphureuine A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Coriolaceae
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • Antineoplastic Agents
  • Sesquiterpenes
  • phellinuin J
  • sulphureuine A