SnapShot: Intrinsic Structural Disorder

Mainak Guharoy; Kris Pauwels; Peter Tompa

doi:10.1016/j.cell.2015.05.024

SnapShot: Intrinsic Structural Disorder

Cell. 2015 May 21;161(5):1230-1230.e1. doi: 10.1016/j.cell.2015.05.024.

Authors

Mainak Guharoy¹, Kris Pauwels¹, Peter Tompa²

Affiliations

¹ VIB Structural Biology Research Center (SBRC), Vlaams Instituut voor Biotechnologie, 1050 Brussel, Belgium; Structural Biology Brussels (SBB), Vrije Universiteit Brussel, 1050 Brussel, Belgium.
² VIB Structural Biology Research Center (SBRC), Vlaams Instituut voor Biotechnologie, 1050 Brussel, Belgium; Structural Biology Brussels (SBB), Vrije Universiteit Brussel, 1050 Brussel, Belgium; Institute of Enzymology, Research Centre for Natural Sciences of the Hungarian Academy of Sciences, 1117 Budapest, Hungary.

PMID: 26000490
DOI: 10.1016/j.cell.2015.05.024

Abstract

Many proteins (intrinsically disordered proteins, IDPs) or regions of proteins (intrinsically disordered regions, IDRs) lack a well-defined 3D structure under physiological conditions. Albeit unfolded and highly dynamic, these proteins are not denatured; rather, intrinsic structural disorder is their native, functional state.

MeSH terms

Animals
Humans
Protein Conformation
Protein Unfolding
Proteins / chemistry*

Substances

Proteins