Alike but Different: RAF Paralogs and Their Signaling Outputs

Enrico Desideri; Anna Lina Cavallo; Manuela Baccarini

doi:10.1016/j.cell.2015.04.045

Alike but Different: RAF Paralogs and Their Signaling Outputs

Cell. 2015 May 21;161(5):967-970. doi: 10.1016/j.cell.2015.04.045.

Authors

Enrico Desideri¹, Anna Lina Cavallo¹, Manuela Baccarini²

Affiliations

¹ Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria.
² Department of Microbiology, Immunology and Genetics; Center of Molecular Biology, University of Vienna; Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9, 1030 Vienna, Austria. Electronic address: manuela.baccarini@univie.ac.at.

PMID: 26000477
DOI: 10.1016/j.cell.2015.04.045

Abstract

RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Carcinogenesis*
Extracellular Signal-Regulated MAP Kinases / metabolism
Humans
MAP Kinase Signaling System*
Neoplasms / metabolism
Proto-Oncogene Proteins c-raf / chemistry
Proto-Oncogene Proteins c-raf / genetics
Proto-Oncogene Proteins c-raf / metabolism*
Signal Transduction

Substances

Proto-Oncogene Proteins c-raf
Extracellular Signal-Regulated MAP Kinases