Abstract
We described for the first time the amino acid substitutions conferring rifampicin resistance in eight Propionibacterium acnes strains isolated from patients with biofilm or device-related infections. We identified different mutations in cluster I and one mutation, never reported, in cluster II of the rpoB gene (I480V) associated with the most frequent one in cluster I (S442L). Half of the patients previously received treatment with rifampicin.
Keywords:
Biofilm; Foreign-body infection; Propionibacterium acnes; Resistance; Rifampicin.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Amino Acid Substitution
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Anti-Bacterial Agents / pharmacology
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Biofilms*
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Catheter-Related Infections / microbiology*
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DNA-Directed RNA Polymerases / genetics*
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Drug Resistance, Bacterial*
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Female
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Mutation, Missense*
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Propionibacterium acnes / drug effects*
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Propionibacterium acnes / isolation & purification
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Rifampin / pharmacology*
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Sequence Analysis, DNA
Substances
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Anti-Bacterial Agents
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
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Rifampin
Associated data
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GENBANK/KC433659
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GENBANK/KC433660
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GENBANK/KC433661
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GENBANK/KC433662
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GENBANK/KC433663
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GENBANK/KC433664
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GENBANK/KJ000556
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GENBANK/KJ486153