Abstract
We coupled folic acid as a tumour targeting ligand to the surface of ferritins and loaded them with ZnF16Pc. The resulting nanoconjugates can efficiently hone in on 4T1 tumours in vivo, and, with photoirradiation, leading to suppressed tumour growth and tumour metastasis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Ferritins / chemistry
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Ferritins / pharmacokinetics*
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Folic Acid
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Materials Testing
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Mice
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Mice, Inbred BALB C
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Nanocapsules / administration & dosage*
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Nanocapsules / chemistry
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Nanocapsules / ultrastructure
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Nanoconjugates / chemistry
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Nanoconjugates / ultrastructure
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Neoplasms, Experimental / drug therapy*
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Neoplasms, Experimental / metabolism*
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Neoplasms, Experimental / pathology
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Photochemotherapy / methods*
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Photosensitizing Agents / administration & dosage*
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Photosensitizing Agents / chemistry
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Treatment Outcome
Substances
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Nanocapsules
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Nanoconjugates
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Photosensitizing Agents
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Ferritins
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Folic Acid