Thermally Switched Release from a Nanogel-in-Microfiber Device

Long Li; Guang Yang; Guangliang Zhou; Yi Wang; Xiaotong Zheng; Shaobing Zhou

doi:10.1002/adhm.201500267

Thermally Switched Release from a Nanogel-in-Microfiber Device

Adv Healthc Mater. 2015 Aug 5;4(11):1658-63. doi: 10.1002/adhm.201500267. Epub 2015 May 21.

Authors

Long Li¹, Guang Yang¹, Guangliang Zhou², Yi Wang¹, Xiaotong Zheng¹, Shaobing Zhou¹

Affiliations

¹ School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Material, Minister of Education, Southwest Jiaotong University, Chengdu, 610031, P. R. China.
² School of Mechanical Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.

PMID: 25998801
DOI: 10.1002/adhm.201500267

Abstract

A nanogel-in-microfiber device, whose release can be switched on and off in response to a temperature change, is successfully developed. The release behaviors are realized through the deswelling and swelling of the nanogels in shell layer of fiber by alternatively elevating and lowering the environmental temperature.

Keywords: cancer therapy; core-shell; nanogels; on-demand release; temperature responsiveness.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / toxicity
Azo Compounds / chemistry
Cell Line, Tumor
Cell Survival / drug effects
Doxorubicin / chemistry
Doxorubicin / toxicity
Drug Carriers / chemistry
Mice
Nanogels
Polyethylene Glycols / chemistry*
Polyethyleneimine / chemistry*
Polymers / chemistry
Temperature

Substances

Antibiotics, Antineoplastic
Azo Compounds
Drug Carriers
Nanogels
Polymers
polyethylene glycol polyethyleneimine nanogel
Polyethylene Glycols
methyl orange
Doxorubicin
Polyethyleneimine