Incident retinal vein occlusions and estimated cerebrospinal fluid pressure. The Beijing Eye Study

Jost B Jonas; Ningli Wang; Ya Xing Wang; Qi Sheng You; Diya Yang; Xiaobin Xie; Liang Xu

doi:10.1111/aos.12575

Incident retinal vein occlusions and estimated cerebrospinal fluid pressure. The Beijing Eye Study

Acta Ophthalmol. 2015 Nov;93(7):e522-6. doi: 10.1111/aos.12575. Epub 2015 May 20.

Authors

Jost B Jonas^{1

2}, Ningli Wang³, Ya Xing Wang¹, Qi Sheng You¹, Diya Yang³, Xiaobin Xie^{3

4}, Liang Xu¹

Affiliations

¹ Beijing Ophthalmology and Visual Science Key Lab, Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
² Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
³ Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
⁴ Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

PMID: 25996958
DOI: 10.1111/aos.12575

Abstract

Purpose: To examine whether the incidence of retinal vein occlusions (RVOs) is associated with estimated cerebrospinal fluid pressure (CSFP).

Methods: The population-based Beijing Eye Study, which included 4439 subjects (age: 40 + years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Fundus photographs were examined for the new development of RVOs, differentiated into central RVOs (CRVOs) and branch RVOs (BRVOs). CSFP was calculated as CSFP [mmHg] = 0.44 × Body Mass Index [kg/m(2) ] + 0.16 × Diastolic Blood Pressure [mmHg]-0.18 × Age[Years].

Results: Incident BRVOs were detected in 50 eyes and incident CRVOs in 8 eyes. BRVOs were located at arterio-venous crossings in 39 eyes. In multivariate analysis, a higher estimated CSFP was associated with a higher incidence of CRVOs (p = 0.004; standardized coefficient beta: 0.06; regression coefficient B: 5.35; 95% confidence interval (CI):1.73, 8.96) after adjusting for urban region (p < 0.001; beta: -0.52; B: -3.93; 95% CI: -4.29, -3.57), higher educational level (p = 0.001; beta: 0.13; B: 0.44; 95% CI: 0.28, 0.60), higher blood concentrations of triglycerides (p < 0.001; beta: 0.08; B: 0.11; 95% CI: 0.05, 0.16) and higher intraocular pressure (p < 0.001; beta: 0.16; B:0.21; 95% CI: 0.16, 0.27). As a corollary, a higher incidence of RVOs as a whole, as well as a higher incidence of CRVOs combined with a higher incidence of BRVOs originating at the optic nerve head, both were significantly associated with higher estimated CSFP (p = 0.002; odds ratio (OR): 1.15; 95% CI: 1.05, 1.25; and p = 0.037; OR: 1.17; 95% CI: 1.01, 1.35, respectively) after adjusting for older age.

Conclusions: A higher estimated CSFP was associated with a higher incidence of RVOs originating at the optic nerve head (i.e. CRVOs, hemi-central RVOs and BRVOs originating at the optic nerve head), and vice versa, a higher incidence of RVOs was associated with a higher estimated CSFP. It suggested an influence of higher estimated CSFP on higher central retinal vein pressure.

Keywords: central retinal vein occlusion; cerebrospinal fluid pressure; glaucoma; trans-lamina cribrosa pressure difference.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Asian People / ethnology*
Blood Pressure / physiology
Body Mass Index
Cerebrospinal Fluid Pressure* / physiology
China / epidemiology
Female
Follow-Up Studies
Humans
Incidence
Intracranial Hypertension / ethnology*
Intracranial Hypertension / physiopathology
Male
Middle Aged
Retinal Vein Occlusion / ethnology*
Retinal Vein Occlusion / physiopathology
Surveys and Questionnaires