Endothelium-derived ET-1 and the development of renal injury

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 1;309(9):R1071-3. doi: 10.1152/ajpregu.00142.2015. Epub 2015 May 20.

Abstract

The role of the vasoactive peptide endothelin-1 (ET-1) in renal injury is not fully understood. In this review, we examine the genetic models available to understand the autocrine/paracrine mechanisms by which ET-1 leads to renal injury and propose the working hypothesis that endothelium-derived ET-1 induces renal injury by initiating renal tubular apoptosis in a paracrine manner.

Keywords: apoptosis; endothelin-1; renal injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Acute Kidney Injury / metabolism*
  • Acute Kidney Injury / pathology
  • Animals
  • Disease Models, Animal*
  • Disease Progression
  • Endothelin-1 / genetics
  • Endothelin-1 / metabolism*
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • Kidney Tubules / metabolism*
  • Mice
  • Mice, Knockout
  • Models, Cardiovascular
  • Paracrine Communication*

Substances

  • Endothelin-1