To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens.
Keywords: Carbapenems; Enterobacter; Enterobacteriaceae; Escherichia coli; Klebsiella infections; Klebsiella pneumonia; Pakistan; United States; antibiotic drugs; antimicrobial resistance; bacteria; beta-Lactam resistance; beta-Lactamases; beta-Lactams; gene transfer; genomics; multilocus sequence typing; next-generation sequencing; phylogeny; plasmids; transposases.