KPC and NDM-1 genes in related Enterobacteriaceae strains and plasmids from Pakistan and the United States

Emerg Infect Dis. 2015 Jun;21(6):1034-7. doi: 10.3201/eid2106.141504.

Abstract

To characterize the genomic context of New Delhi metallo-β-lactamase-1 (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC), we sequenced 78 Enterobacteriaceae isolates from Pakistan and the United States encoding KPC, NDM-1, or no carbapenemase. High similarities of the results indicate rapid spread of carbapenem resistance between strains, including globally disseminated pathogens.

Keywords: Carbapenems; Enterobacter; Enterobacteriaceae; Escherichia coli; Klebsiella infections; Klebsiella pneumonia; Pakistan; United States; antibiotic drugs; antimicrobial resistance; bacteria; beta-Lactam resistance; beta-Lactamases; beta-Lactams; gene transfer; genomics; multilocus sequence typing; next-generation sequencing; phylogeny; plasmids; transposases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics*
  • Carbapenems / pharmacology
  • Computational Biology / methods
  • Enterobacteriaceae / classification
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae Infections / epidemiology*
  • Enterobacteriaceae Infections / microbiology*
  • Genomics / methods
  • Humans
  • Microbial Sensitivity Tests
  • Pakistan / epidemiology
  • Plasmids / genetics*
  • United States / epidemiology
  • beta-Lactam Resistance
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • beta-Lactamases
  • beta-lactamase NDM-1
  • carbapenemase

Associated data

  • BioProject/PRJNA261540