Models and mechanisms of vascular dementia

Poornima Venkat; Michael Chopp; Jieli Chen

doi:10.1016/j.expneurol.2015.05.006

Models and mechanisms of vascular dementia

Exp Neurol. 2015 Oct:272:97-108. doi: 10.1016/j.expneurol.2015.05.006. Epub 2015 May 15.

Authors

Poornima Venkat¹, Michael Chopp², Jieli Chen³

Affiliations

¹ Neurology, Henry Ford Hospital, Detroit, MI, USA; Physics, Oakland University, Rochester, MI, USA. Electronic address: pvenkat3@hfhs.org.
² Neurology, Henry Ford Hospital, Detroit, MI, USA; Physics, Oakland University, Rochester, MI, USA. Electronic address: mchopp1@hfhs.org.
³ Neurology, Henry Ford Hospital, Detroit, MI, USA; Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin Geriatrics Institute, Tianjin, China. Electronic address: jieli@neuro.hfh.edu.

Abstract

Vascular dementia (VaD) is the second leading form of dementia after Alzheimer's disease (AD) plaguing the elderly population. VaD is a progressive disease caused by reduced blood flow to the brain, and it affects cognitive abilities especially executive functioning. VaD is poorly understood and lacks suitable animal models, which constrain the progress on understanding the basis of the disease and developing treatments. This review article discusses VaD, its risk factors, induced cognitive disability, various animal (rodent) models of VaD, pathology, and mechanisms of VaD and treatment options.

Keywords: Cognition; High fat diet; Multiple infarct dementia; Treatment; Vascular dementia.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / etiology
Animals
Cognition Disorders / etiology*
Dementia, Vascular / complications*
Dementia, Vascular / etiology*
Disease Models, Animal*
Disease Progression
Humans
Hypertension / complications
Metabolic Diseases / complications
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding