Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Sang-Bing Ong; Siavash Beikoghli Kalkhoran; Hector A Cabrera-Fuentes; Derek J Hausenloy

doi:10.1016/j.ejphar.2015.04.056

Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease

Eur J Pharmacol. 2015 Sep 15;763(Pt A):104-14. doi: 10.1016/j.ejphar.2015.04.056. Epub 2015 May 16.

Authors

Sang-Bing Ong¹, Siavash Beikoghli Kalkhoran², Hector A Cabrera-Fuentes³, Derek J Hausenloy⁴

Affiliations

¹ Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia.
² The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK.
³ Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany; Department of Microbiology, Kazan Federal University, Kazan, Russian Federation.
⁴ Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, UK; The National Institute of Health Research University College London Hospitals Biomedical Research Centre, UK. Electronic address: derek.hausenloy@duke-nus.edu.sg.

Abstract

The past decade has witnessed a number of exciting developments in the field of mitochondrial dynamics - a phenomenon in which changes in mitochondrial shape and movement impact on cellular physiology and pathology. By undergoing fusion and fission, mitochondria are able to change their morphology between elongated interconnected networks and discrete fragmented structures, respectively. The cardiac mitochondria, in particular, have garnered much interest due to their unique spatial arrangement in the adult cardiomyocyte, and the multiple roles they play in cell death and survival. In this article, we review the role of the mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease.

Keywords: Calcineurin (PubChem CID:16219117); Chemical compounds studied in this article; Drp1; Dynasore (PubChem CID:5717066); MFN1; MFN2; Mitochondrial fission; Mitochondrial fusion; OPA1; Phenylephrine (PubChem CID:6041); mdivi-1 (PubChem CID:3825829).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cardiovascular Diseases / drug therapy*
Cardiovascular Diseases / metabolism*
Cardiovascular Diseases / pathology
Humans
Mitochondrial Dynamics / drug effects*
Mitochondrial Proteins / metabolism*
Molecular Targeted Therapy / methods*

Substances

Mitochondrial Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding