A supramolecular approach to improve the gene transfection efficacy of dendrimers

Chem Commun (Camb). 2015 Jun 14;51(47):9741-3. doi: 10.1039/c5cc02300a.

Abstract

Cyanuric acid is able to form complementary hydrogen bonds with melamine. Here, the specific recognition between cyanuric acid and melamine is used to significantly improve the gene transfection efficacy of low generation dendrimers via a supramolecular approach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival / drug effects
  • Dendrimers / chemistry*
  • Dendrimers / pharmacology*
  • Dose-Response Relationship, Drug
  • Gene Transfer Techniques*
  • HEK293 Cells
  • Humans
  • Hydrogen Bonding
  • Molecular Structure
  • Triazines / chemistry*

Substances

  • Dendrimers
  • Triazines
  • cyanuric acid
  • melamine