Highly diastereoselective synthesis of spiropyrazolones

Molecules. 2015 May 13;20(5):8574-82. doi: 10.3390/molecules20058574.

Abstract

We report a highly diastereoselective synthesis of spiropyrazolones catalyzed by secondary amines. The reported Michael-Aldol cascade reaction affords the desired spiropyrazolones bearing four chiral centers as a single diastereomer in excellent yields.

Keywords: cascade reaction; diastereoselective; spiropyrazolones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry
  • Catalysis
  • Molecular Structure
  • Pyrazolones / chemical synthesis*
  • Pyrazolones / chemistry
  • Spiro Compounds / chemical synthesis*
  • Spiro Compounds / chemistry
  • Stereoisomerism

Substances

  • Amines
  • Pyrazolones
  • Spiro Compounds