Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection

Cytokine. 2015 Dec;76(2):152-155. doi: 10.1016/j.cyto.2015.04.019. Epub 2015 May 14.

Abstract

Urogenital schistosomiasis caused by Schistosoma haematobium induces a Th2 immune response, including expression of Interleukin-6. IL-6 confers protection from experimental Schistosoma-induced pulmonary hypertension and modulates production of mannose-binding lectin (MBL) and other lectins. We studied IL-6 levels in schistosomiasis and its effect on lectins production. Elevated IL-6 levels occurred in cases, compared to controls. IL-6 correlated with the lectins MBL, ficolin-2 and Collectin Kidney-1 (CL-K1) in cases, but correlated inversely in controls. The study shows that IL-6 levels are elevated in individuals infected with urogenital schistosomiasis. IL-6 was also found to be correlated with the production of lectins in S. haematobium infection. A similar correlation between IL-6 and MBL was observed during visceral leishmaniasis.

Keywords: CL-K1; Ficolin-2; IL-6; MBL; Schistosomiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Helminth / blood
  • Collectins / blood
  • Cross-Sectional Studies
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Lectins / blood*
  • Leishmania donovani
  • Leishmaniasis, Visceral / immunology
  • Male
  • Mannose-Binding Lectin / blood
  • Mannose-Binding Lectin / chemistry
  • Nigeria / epidemiology
  • Parasite Egg Count
  • Schistosoma haematobium / immunology
  • Schistosomiasis haematobia / epidemiology
  • Schistosomiasis haematobia / immunology*
  • Schistosomiasis haematobia / parasitology

Substances

  • Antibodies, Helminth
  • Collectins
  • IL6 protein, human
  • Interleukin-6
  • Lectins
  • Mannose-Binding Lectin