Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

Simon M Rice; Miriam R Schäfer; Claudia Klier; Nilufar Mossaheb; Nandita Vijayakumar; Günter Paul Amminger

doi:10.1016/j.psychres.2015.04.036

Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls

Psychiatry Res. 2015 Jul 30;228(1):174-6. doi: 10.1016/j.psychres.2015.04.036. Epub 2015 May 2.

Authors

Simon M Rice¹, Miriam R Schäfer¹, Claudia Klier², Nilufar Mossaheb³, Nandita Vijayakumar⁴, Günter Paul Amminger⁵

Affiliations

¹ Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, The University of Melbourne, Australia.
² Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
³ Department of Psychiatry and Psychotherapy, Clinical Division of Social Psychiatry, Medical University Vienna, Austria.
⁴ Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, The University of Melbourne, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Australia.
⁵ Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, The University of Melbourne, Australia. Electronic address: amminger@unimelb.edu.au.

PMID: 25979466
DOI: 10.1016/j.psychres.2015.04.036

Abstract

Erythrocyte polyunsaturated fatty acid (PUFA) levels from individuals at ultra-high risk (UHR) for psychosis (n = 80) were compared to existing data from healthy controls (n = 142). Results demonstrated PUFA deficits (α-linolenic acid, eicosapentanoic acid, all ω-6 PUFAs) for the UHR group. Findings provide a rationale for PUFA based interventions in emerging psychosis.

Keywords: Polyunsaturated fatty acids; Psychosis; Ultra-high risk.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Erythrocytes / metabolism*
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Female
Humans
Male
Psychotic Disorders / blood*
Risk
Young Adult

Substances

Fatty Acids, Omega-3
Fatty Acids, Omega-6