Chemical composition, N-nitrosamine inhibition and antioxidant and antimicrobial properties of essential oil from Coreopsis tinctoria flowering tops

Nat Prod Res. 2016;30(10):1170-3. doi: 10.1080/14786419.2015.1041943. Epub 2015 May 15.

Abstract

Coreopsis tinctoria flowering (CTF) tops from the Kunlun Mountains in Xinjing (north-western China) have been used for tea production for about a century. This study was to assess antioxidant, nitrite-scavenging and N-nitrosamine inhibitory and antimicrobial activities of the essential oil extracted from CTF tops. The essential oil was extracted through hydrodistillation and its chemical compositions were analysed by GC-MS. Seventy compounds of the oil were identified, representing 81.87% of total oil. The antioxidant capacities of the oil with IC50 values for scavenging DPPH and ABTS were 287.66 ± 12.60 and 1.251 ± 0.127 μg mL(- 1), respectively. The nitrite-scavenging and N-nitrosamine inhibitory activities (IC50) were 0.3912 ± 0.0127 and 0.6564 ± 0.036 μg mL(- 1), respectively. The oil has a certain antimicrobial capacity, but its capacity was weaker than that of penicillinG (24 μg mL(- 1)). The oil showed antioxidant and antimicrobial capacities and had a stronger nitrite-scavenging and N-nitrosamine inhibitory properties.

Keywords: Coreopsis tinctoria Nutt; N-nitrosamine inhibition; antimicrobial activity; antioxidant activity; chemical compositions; essential oil.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Antioxidants / chemistry*
  • Antioxidants / isolation & purification
  • China
  • Coreopsis / chemistry*
  • Flowering Tops / chemistry
  • Gas Chromatography-Mass Spectrometry
  • Microbial Sensitivity Tests
  • Nitrosamines / antagonists & inhibitors*
  • Oils, Volatile / chemistry*
  • Plant Extracts / chemistry
  • Plant Oils / chemistry*

Substances

  • Anti-Bacterial Agents
  • Antioxidants
  • Nitrosamines
  • Oils, Volatile
  • Plant Extracts
  • Plant Oils