Synthesis and characterization of cell-microenvironment-sensitive leakage-free gold-shell nanoparticles with the template of interlayer-crosslinked micelles

Chem Commun (Camb). 2015 Jun 14;51(47):9682-5. doi: 10.1039/c5cc02556g.

Abstract

Novel gold-shell nanoparticles (pH-GSNPs) are designed for the first time, which exhibit drug leakage-free behavior in a physiological environment, while achieving rapid drug release and remarkable aggregation for the nanogold interlayer of pH-GSNPs to shift their absorption to far-red and NIR as a photothermal agent in the intracellular microenvironment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Cross-Linking Reagents
  • Doxorubicin / pharmacology*
  • Drug Carriers*
  • Female
  • Gold / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Metal Nanoparticles / chemistry*
  • Micelles*
  • Ovarian Neoplasms / drug therapy*
  • Tumor Cells, Cultured
  • Tumor Microenvironment / drug effects*

Substances

  • Antineoplastic Agents
  • Cross-Linking Reagents
  • Drug Carriers
  • Micelles
  • Gold
  • Doxorubicin