Abstract
In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Apoptosis / drug effects*
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Cell Line, Tumor
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Chromatography, High Pressure Liquid
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Cyclophosphamide / pharmacology*
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Female
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Humans
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In Situ Nick-End Labeling
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Injections, Intravenous
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Jurkat Cells
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Methylmalonic Acid / administration & dosage
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Methylmalonic Acid / analogs & derivatives*
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Methylmalonic Acid / chemical synthesis
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Methylmalonic Acid / chemistry
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Methylmalonic Acid / isolation & purification
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Methylmalonic Acid / pharmacology*
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Mice, Nude
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Molecular Imaging / methods*
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Positron-Emission Tomography / methods*
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Tissue Distribution
Substances
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2-(3-fluoropropyl)-2-methylmalonic acid
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Methylmalonic Acid
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Cyclophosphamide