While most published articles on oral anti diabetic therapy approve of metformin, few discuss what should be done if metformin is contraindicated or not tolerated. This article defines metformin intolerance, and discusses various pharmacological options available for persons with type 2 diabetes who cannot take metformin and do not accept/require insulin.
Keywords: Metformin intolerance, type 2 diabetes, sulfonylureas, alpha glucosidase inhibitors, pioglitazone, SGLT2 inhibitors, DPP4 inhibitors..