Abstract
Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
MeSH terms
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Animals
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Antigens, Bacterial / genetics
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Antigens, Surface
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / genetics
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Bacterial Vaccines / immunology*
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Borrelia burgdorferi / genetics
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Borrelia burgdorferi / immunology*
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Dog Diseases / immunology*
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Dog Diseases / prevention & control*
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Dogs
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Lipoproteins / deficiency
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Lyme Disease / immunology
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Lyme Disease / prevention & control
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Lyme Disease / veterinary*
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Placebos
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Treatment Outcome
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Vaccination / methods*
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Vaccines, Attenuated / administration & dosage
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology
Substances
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Antigens, Bacterial
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Antigens, Surface
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Bacterial Outer Membrane Proteins
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Bacterial Vaccines
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Lipoproteins
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OspA protein
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Placebos
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Vaccines, Attenuated
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OspB protein, Borrelia burgdorferi