Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease

Clin Vaccine Immunol. 2015 Jul;22(7):836-9. doi: 10.1128/CVI.00193-15. Epub 2015 May 13.

Abstract

Beagles received placebo or ospA- and ospB-negative Borrelia burgdorferi before a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n = 10) contained B. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n = 10) were infected (P = 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P = 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P = 0.0573). Therefore, vaccination with the ospA- and ospB-negative spirochete provided significant protection against Lyme disease.

Publication types

  • Clinical Study

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics
  • Antigens, Surface
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / genetics
  • Bacterial Vaccines / immunology*
  • Borrelia burgdorferi / genetics
  • Borrelia burgdorferi / immunology*
  • Dog Diseases / immunology*
  • Dog Diseases / prevention & control*
  • Dogs
  • Lipoproteins / deficiency
  • Lyme Disease / immunology
  • Lyme Disease / prevention & control
  • Lyme Disease / veterinary*
  • Placebos
  • Treatment Outcome
  • Vaccination / methods*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / genetics
  • Vaccines, Attenuated / immunology

Substances

  • Antigens, Bacterial
  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • OspA protein
  • Placebos
  • Vaccines, Attenuated
  • OspB protein, Borrelia burgdorferi