Deubiquitinases in cancer

Rongbin Wei; Xiaodong Liu; Weixin Yu; Tianshu Yang; Wenping Cai; Junjun Liu; Xiao Huang; Guo-tong Xu; Shouliang Zhao; Jianhua Yang; Shangfeng Liu

doi:10.18632/oncotarget.3671

Deubiquitinases in cancer

Oncotarget. 2015 May 30;6(15):12872-89. doi: 10.18632/oncotarget.3671.

Authors

Affiliations

¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China.
² Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.
³ Department of Stomatology, Huashan Hospital, Fudan University, Shanghai 200040, P. R. China.

Abstract

Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.

Keywords: cancer; deubiquitinases; inhibitor; ubiquitylation.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Humans
Molecular Targeted Therapy
Neoplasms / drug therapy
Neoplasms / enzymology*
Ubiquitin / metabolism
Ubiquitin-Specific Proteases / metabolism*

Substances

Antineoplastic Agents
Ubiquitin
Ubiquitin-Specific Proteases