A simple fluorescent off-on probe for the discrimination of cysteine from glutathione

Chem Commun (Camb). 2015 Jun 7;51(45):9388-90. doi: 10.1039/c5cc02788h.

Abstract

A simple and stable fluorescent off-on probe for discrimination of cysteine (Cys) from glutathione (GSH) has been developed by combining resorufin with 7-nitrobenzofurazan. The probe, displaying distinct emission patterns for Cys and GSH at just one excitation wavelength, can be used for simultaneous determination of Cys and GSH in human plasma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine / blood
  • Cysteine / chemistry*
  • Fluorescent Dyes / chemistry*
  • Glutathione / blood
  • Glutathione / chemistry*
  • Humans
  • Molecular Structure

Substances

  • Fluorescent Dyes
  • Glutathione
  • Cysteine