Abstract
The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin Bı (AFBı) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFBı-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFBı.
Keywords:
Mn(III) complexes; aflatoxin Bı; antimicrobial properties; mutagenicity.
MeSH terms
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Aflatoxin B1* / antagonists & inhibitors
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Aflatoxin B1* / toxicity
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Antidotes* / chemistry
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Antidotes* / pharmacology
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Azo Compounds* / chemistry
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Azo Compounds* / pharmacology
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Bacteria / growth & development
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Female
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Humans
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Male
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Manganese* / chemistry
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Manganese* / pharmacology
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Serine* / chemistry
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Serine* / pharmacology
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Thiosemicarbazones* / chemistry
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Thiosemicarbazones* / pharmacology
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Threonine* / chemistry
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Threonine* / pharmacology
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Tyrosine* / chemistry
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Tyrosine* / pharmacology
Substances
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Anti-Bacterial Agents
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Antidotes
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Azo Compounds
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Thiosemicarbazones
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azomethine
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Threonine
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Tyrosine
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Manganese
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Serine
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Aflatoxin B1