PharmGKB summary: Efavirenz pathway, pharmacokinetics

Pharmacogenet Genomics. 2015 Jul;25(7):363-76. doi: 10.1097/FPC.0000000000000145.

Authors

Ellen M McDonagh¹, Johnathan L Lau, Maria L Alvarellos, Russ B Altman, Teri E Klein

Affiliation

¹ Departments of aGenetics bBioengineering, School of Medicine, Stanford University, Stanford, California, USA cDepartment of Immunology, University of Toronto, Toronto, Ontario, Canada.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

ATP Binding Cassette Transporter, Subfamily B / genetics
ATP Binding Cassette Transporter, Subfamily B / metabolism
Alkynes
Anti-HIV Agents / administration & dosage
Anti-HIV Agents / adverse effects
Anti-HIV Agents / pharmacokinetics*
Benzoxazines / administration & dosage
Benzoxazines / adverse effects
Benzoxazines / pharmacokinetics*
Cyclopropanes
Cytochrome P-450 CYP2A6 / genetics
Cytochrome P-450 CYP2A6 / metabolism
Cytochrome P-450 CYP2B6 / genetics
Cytochrome P-450 CYP2B6 / metabolism
Cytochrome P-450 CYP3A / genetics
Cytochrome P-450 CYP3A / metabolism
Drug Interactions
Glucuronosyltransferase / genetics
Glucuronosyltransferase / metabolism
HIV Infections / drug therapy
HIV Infections / genetics
HIV Infections / metabolism
HIV-1
Humans
Metabolic Networks and Pathways
Polymorphism, Single Nucleotide
Reverse Transcriptase Inhibitors / administration & dosage
Reverse Transcriptase Inhibitors / adverse effects
Reverse Transcriptase Inhibitors / pharmacokinetics*

Substances

ABCB1 protein, human
ATP Binding Cassette Transporter, Subfamily B
Alkynes
Anti-HIV Agents
Benzoxazines
Cyclopropanes
Reverse Transcriptase Inhibitors
CYP2A6 protein, human
CYP2B6 protein, human
CYP3A5 protein, human
Cytochrome P-450 CYP2A6
Cytochrome P-450 CYP2B6
Cytochrome P-450 CYP3A
CYP3A4 protein, human
UGT2B7 protein, human
Glucuronosyltransferase
efavirenz

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