Abstract
An unusual 5-C-methylated-dihydrobenzofuroisocoumarin, named multifidarin A (1), and two new ent-kaurane diterpenoids, named multikauranes A (2) and B (3), together with three known ent-kaurane diterpenoids, were isolated from the whole plants of Pteris multifida. The structures of 1-3 were elucidated by spectroscopic methods. The cytotoxic activities of all new compounds were evaluated against five human tumor cell lines. A possible biosynthetic process for the formation of 1 is proposed.
Keywords:
Pteridaceae; Pteris multifida; ent-kaurane diterpenoids; isocoumarin; multifidarin A; multikaurane.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Diterpenes, Kaurane / chemistry
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pteris / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Coumarins
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Diterpenes, Kaurane
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Drugs, Chinese Herbal
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multifidarin A
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multikaurane A
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multikaurane B