CuSO4/KI As Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazolo-Nucleosides

Hanane Elayadi; Hassan Bihi Lazrek

doi:10.1080/15257770.2015.1014047

CuSO4/KI As Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazolo-Nucleosides

Nucleosides Nucleotides Nucleic Acids. 2015;34(6):433-41. doi: 10.1080/15257770.2015.1014047.

Authors

Hanane Elayadi¹, Hassan Bihi Lazrek

Affiliation

¹ a Laboratory of Biomolecular and Medicinal Chemistry, Faculty of Science Semlalia , Cadi Ayyad University , Marrakech , Morocco.

PMID: 25965332
DOI: 10.1080/15257770.2015.1014047

Abstract

A simple and inexpensive procedure has been developed for the selective formation of 1,4-disubstituted-1,2,3-triazolo-nucleosides starting from organic azides and terminal alkynes, mediated by in situ generated copper(I) catalyst from readily available CuSO4 and KI.

Keywords: 1,2,3-triazolyl nucleoside; Copper catalysts; CuSO4/KI; click reaction; one-pot [3+2] cycloaddition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper Sulfate / chemistry*
Nucleosides / chemical synthesis*
Nucleosides / chemistry
Potassium Iodide / chemistry*
Triazoles / chemistry*

Substances

Nucleosides
Triazoles
Potassium Iodide
Copper Sulfate