Efficient synthesis of cytidine diphosphate choline (CDP-choline) and its analogs

Qi Sun; Xiao-Chuan Li; Shan-Shan Gong; Jian Sun; Cheng-Jun Wang; Xing-Cong Wang

doi:10.1080/15257770.2015.1004340

Efficient synthesis of cytidine diphosphate choline (CDP-choline) and its analogs

Nucleosides Nucleotides Nucleic Acids. 2015;34(6):379-87. doi: 10.1080/15257770.2015.1004340.

Authors

Qi Sun¹, Xiao-Chuan Li, Shan-Shan Gong, Jian Sun, Cheng-Jun Wang, Xing-Cong Wang

Affiliation

¹ a Jiangxi Key Laboratory of Organic Chemistry , Jiangxi Science and Technology Normal University , Nanchang , Jiangxi , PR China.

PMID: 25965327
DOI: 10.1080/15257770.2015.1004340

Abstract

An efficient P(V)-N activation approach for the synthesis of cytidine diphosphate choline (CDP-choline) and related ribo- and deoxyribonucleotide analogs has been established.

Keywords: 4,5-dicyanoimidazole; CDP-choline; P(V)–N activation; phosphocholine; phosphoropiperidate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytidine Diphosphate Choline / analogs & derivatives*
Cytidine Diphosphate Choline / chemical synthesis*
Cytidine Diphosphate Choline / chemistry*

Substances

Cytidine Diphosphate Choline