Molecular epidemiology of severe respiratory disease by human rhinoviruses and enteroviruses at a tertiary paediatric hospital in Barcelona, Spain

Clin Microbiol Infect. 2015 Aug;21(8):799.e5-7. doi: 10.1016/j.cmi.2015.04.021. Epub 2015 May 8.

Abstract

In order to describe the molecular epidemiology of human rhinovirus (HRV) and enterovirus (EV) infection in severely ill children, we studied all episodes of bronchospasm/bronchopneumonia in 6-month-old to 18-year-old patients from January 2010 to May 2012 who required mechanical ventilation. HRV/EVs were detected in 55 (57.3%) of 96 patients, of which 50 (91%) were HRV (HRV-A, 16; HRV-B, 1; HRV-C, 18) and 5 (9%) were EVs (EV-D68, 3). No significant differences in epidemiologic and clinical characteristics were found between different types. In six of the 13 patients who required invasive mechanical ventilation, HRV was the only pathogen detected.

Keywords: Enterovirus; molecular epidemiology; paediatric intensive care; respiratory viruses; rhinovirus; types.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Enterovirus / classification
  • Enterovirus / genetics
  • Enterovirus / isolation & purification*
  • Female
  • Humans
  • Infant
  • Male
  • Molecular Epidemiology
  • Picornaviridae Infections / epidemiology*
  • Picornaviridae Infections / pathology
  • Picornaviridae Infections / therapy
  • Picornaviridae Infections / virology
  • Prevalence
  • Prospective Studies
  • Respiration, Artificial
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / pathology
  • Respiratory Tract Infections / therapy
  • Respiratory Tract Infections / virology
  • Rhinovirus / classification
  • Rhinovirus / genetics
  • Rhinovirus / isolation & purification*
  • Spain / epidemiology
  • Tertiary Care Centers