Enhancement of cancer specific delivery using ultrasound active bio-originated particles

Chem Commun (Camb). 2015 Jun 11;51(46):9455-8. doi: 10.1039/c5cc01440a.

Abstract

A hybrid multifunctional particle comprising of a microbbule (MB), liposome (Lipo), and an Fe ion chelated melanin nanoparticle (MNP(Fe)) was applied for ultrasound mediated cancer targeting as a theranostic agent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Drug Delivery Systems*
  • Humans
  • Inhibitor of Apoptosis Proteins / genetics
  • Iron / administration & dosage*
  • Liposomes
  • Melanins / administration & dosage*
  • Microbubbles*
  • Nanoparticles / administration & dosage*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism
  • RNA, Small Interfering / administration & dosage
  • Receptor, ErbB-2 / metabolism
  • Survivin
  • Ultrasonics

Substances

  • BIRC5 protein, human
  • Inhibitor of Apoptosis Proteins
  • Liposomes
  • Melanins
  • RNA, Small Interfering
  • Survivin
  • Iron
  • ERBB2 protein, human
  • Receptor, ErbB-2