Haunting the HOXA Locus: Two Faces of lncRNA Regulation

Nianwei Lin; Jason Dang; Tariq M Rana

doi:10.1016/j.stem.2015.04.010

Haunting the HOXA Locus: Two Faces of lncRNA Regulation

Cell Stem Cell. 2015 May 7;16(5):449-50. doi: 10.1016/j.stem.2015.04.010.

Authors

Nianwei Lin¹, Jason Dang¹, Tariq M Rana²

Affiliations

¹ Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.
² Department of Pediatrics, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: trana@ucsd.edu.

PMID: 25957895
DOI: 10.1016/j.stem.2015.04.010

Abstract

Long non-coding RNAs (lncRNAs) regulate diverse biological functions through mechanisms ascribed to the lncRNA transcript itself. Now in Cell Stem Cell, Yin et al. (2015) use CRISPR/Cas9-mediated genome editing to demonstrate discrete and opposing roles for the lncRNA Haunt transcript and DNA at the HOXA locus during ESC differentiation.

Publication types

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MeSH terms

Animals
Embryonic Stem Cells / physiology*
Homeodomain Proteins / metabolism*
RNA, Long Noncoding / metabolism*

Substances

Homeodomain Proteins
RNA, Long Noncoding