A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging

Juan Mou; Chengbo Liu; Pei Li; Yu Chen; Huixiong Xu; Chenyang Wei; Liang Song; Jianlin Shi; Hangrong Chen

doi:10.1016/j.biomaterials.2015.04.020

A facile synthesis of versatile Cu2-xS nanoprobe for enhanced MRI and infrared thermal/photoacoustic multimodal imaging

Biomaterials. 2015 Jul:57:12-21. doi: 10.1016/j.biomaterials.2015.04.020. Epub 2015 Apr 22.

Authors

Juan Mou¹, Chengbo Liu², Pei Li³, Yu Chen¹, Huixiong Xu³, Chenyang Wei¹, Liang Song⁴, Jianlin Shi¹, Hangrong Chen⁵

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China.
² Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China.
³ Tenth People's Hospital of Tongji University, Shanghai 200072, PR China.
⁴ Research Lab for Biomedical Optics and Molecular Imaging, Shenzhen Key Lab for Molecular Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China. Electronic address: liang.song@siat.ac.cn.
⁵ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: hrchen@mail.sic.ac.cn.

PMID: 25956193
DOI: 10.1016/j.biomaterials.2015.04.020

Abstract

A novel type of intelligent nanoprobe by using single component of Cu2-xS for multimodal imaging has been facilely and rapidly synthesized in scale via thermal decomposition followed by biomimetic phospholipid modification, which endows them with uniform and small nanoparticle size (ca.15 nm), well phosphate buffer saline (PBS) dispersity, high stability, and excellent biocompatibility. The as-synthesized Cu2-xS nanoprobes (Cu2-xS NPs) are capable of providing contrast enhancement for T1-weighted magnetic resonance imaging (MRI), as demonstrated by the both in vitro and in vivo imaging investigations for the first time. In addition, due to their strong near infrared (NIR) optical absorption, they can also serve as a candidate contrast agent for enhanced infrared thermal/photoacoustic imaging, to meet the shortfalls of MRI. Hence, complementary and potentially more comprehensive information can be acquired for the early detection and accurate diagnosis of cancer. Furthermore, negligible systematic side effects to the blood and tissue were observed in a relatively long period of 3 months. The distinctive multimodal imaging capability with excellent hemo/histocompatibility of the Cu2-xS NPs could open up a new molecular imaging possibility for detecting and diagnosing cancer or other diseases in the future.

Keywords: Contrast agent; Cu(2−x)S nanoprobe; Infrared thermal imaging; Magnetic resonance imaging; Photoacoustic imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media* / analysis
Contrast Media* / chemical synthesis
Copper* / analysis
HeLa Cells
Humans
Infrared Rays
Magnetic Resonance Imaging / methods*
Mice
Multimodal Imaging / methods*
Nanoparticles* / analysis
Nanoparticles* / ultrastructure
Neoplasms / diagnosis*
Optical Imaging / methods
Photoacoustic Techniques / methods*
Sulfur / analysis
Temperature

Substances

Contrast Media
Sulfur
Copper