A genotoxic analysis of the hematopoietic system after mobile phone type radiation exposure in rats

Int J Radiat Biol. 2015 Aug;91(8):664-72. doi: 10.3109/09553002.2015.1047988. Epub 2015 Jun 3.

Abstract

Purpose: In our earlier study we reported that 900 MHz continuous wave (CW) radiofrequency radiation (RFR) exposure (2 W/kg specific absorption rate [SAR]) had no significant effect on the hematopoietic system of rats. In this paper we extend the scope of the previous study by testing for possible effects at: (i) different SAR levels; (ii) both 900 and 1800 MHz, and; (iii) both CW and pulse modulated (PM) RFR.

Materials and methods: Excised long bones from rats were placed in medium and RFR exposed in (i) a Transverse Electromagnetic (TEM) cell or (ii) a waveguide. Finite-difference time-domain (FDTD) numerical analyses were used to estimate forward power needed to produce nominal SAR levels of 2/10 and 2.5/12.4 W/kg in the bone marrow. After exposure, the lymphoblasts were extracted and assayed for proliferation rate, and genotoxicity.

Results: Our data did not indicate any significant change in these end points for any combination of CW/PM exposure at 900/1800 MHz at SAR levels of nominally 2/10 W/kg or 2.5/12.4 W/kg.

Conclusions: No significant changes were observed in the hematopoietic system of rats after the exposure of CW/PM wave 900 MHz/1800 MHz RF radiations at different SAR values.

Keywords: DNA damage; Mobile phones; comet assay; hematopoietic cells; proliferation; radiation physics; radiofrequency radiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / physiology*
  • Bone Marrow Cells / radiation effects*
  • Cell Phone*
  • Cell Proliferation / physiology
  • Cell Proliferation / radiation effects
  • Cells, Cultured
  • Chromosome Aberrations / radiation effects*
  • Dose-Response Relationship, Radiation
  • Male
  • Microwaves
  • Mutagenicity Tests / methods*
  • Radiation Dosage
  • Radiation Exposure / analysis*
  • Rats
  • Rats, Sprague-Dawley