Adult stem-like cells exclude "older" mitochondria

Michael A Teitell

doi:10.1016/j.cmet.2015.04.023

Adult stem-like cells exclude "older" mitochondria

Cell Metab. 2015 May 5;21(5):658-9. doi: 10.1016/j.cmet.2015.04.023.

Author

Michael A Teitell¹

Affiliation

¹ Departments of Pathology and Laboratory Medicine, Pediatrics, and Bioengineering, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, Broad Stem Cell Research Center, and California NanoSystems Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: mteitell@ucla.edu.

Abstract

Asymmetric distribution of damaged cellular constituents may occur during mitosis, resulting in more and less pristine daughter cell pairs. In Science, Katajisto et al., (2015) report that mammary stem-like cells (SLCs) unequally apportion older mitochondria to post-division daughter cells, with the daughter containing younger mitochondria maintaining the SLC pool.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Division / physiology*
Cellular Senescence / physiology*
Humans
Mitochondria / physiology*
Stem Cells / physiology*
Stem Cells / ultrastructure*

Abstract

Publication types

MeSH terms

Grants and funding