Neuroinvasive cryptococcosis in an immunocompetent patient with a negative spinal fluid cryptococcus antigen

Rocio C Garcia-Santibanez; Veenu Gill; Stanley Yancovitz; DeWitt Pyburn

doi:10.1155/2015/857539

Neuroinvasive cryptococcosis in an immunocompetent patient with a negative spinal fluid cryptococcus antigen

Case Rep Infect Dis. 2015:2015:857539. doi: 10.1155/2015/857539. Epub 2015 Apr 14.

Authors

Rocio C Garcia-Santibanez¹, Veenu Gill², Stanley Yancovitz², DeWitt Pyburn¹

Affiliations

¹ Department of Neurology, Mount Sinai Beth Israel, New York, NY 10003, USA.
² Department of Infectious Diseases, Mount Sinai Beth Israel, New York, NY 10003, USA.

Abstract

58-year-old man presented with headache, nausea, vomiting, and gait disturbance. Brain MRI showed meningeal enhancement and herniation. Serum Cryptococcus antigen was positive but spinal fluid antigen and cultures were negative. A cerebellar biopsy revealed nonencapsulated Cryptococcus. He completed antifungal therapy. Serum Cryptococcus antigen titer decreased. He had a full neurological recovery.